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10
|
|
Multidomain interaction governs the filamentous assembly of the dominant-negative DNMT3A R882H mutant.
(pnas.org)
|
Chen J
…
Song J
PNAS
2026-08-25
|
#cryo-em
#protein structure
#methyltransferase
#epigenetics
#leukemia
|
|
8
|
|
Myeloproliferative Neoplasms.
(nejm.org)
|
Plo I
…
Vainchenker W
New England Journal of Medicine
2026-08-20
|
#myeloproliferative
#jak2
#hematology
#leukemia
#immunotherapy
|
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3
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|
A phase 1 feasibility trial of BE-CAR33, an "off-the-shelf" base-edited CAR33 T cell therapy for acute myeloid leukemia.
(science.org)
|
Georgiadis C
…
Qasim W
Science Translational Medicine
2026-08-19
|
#immunotherapy
#leukemia
#car-t
#base-editing
#transplantation
|
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2
|
|
L-asparaginase reversibly suppresses CD40-mediated B cell activation and antigen-presenting function by metabolic restriction.
(linkinghub.elsevier.com)
|
Hadzic A
…
Theurich S
iScience
2026-08-21
|
#metabolism
#immunity
#lymphocyte
#immunosuppression
#leukemia
|
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2
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|
Space radiation promotes clonal hematopoiesis and hematologic disease upon aging in a driver gene and sex-specific manner.
(linkinghub.elsevier.com)
|
Evans MA
…
Walsh K
iScience
2026-08-21
|
#hematopoiesis
#radiation
#clonal_expansion
#leukemia
#aging
|
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0
|
|
Beyond BCL-2: What drives venetoclax resistance in acute myeloid leukemia?
(linkinghub.elsevier.com)
|
Skwarska A
…
Konopleva M
Cancer Cell
2026-08-10
|
#leukemia
#amr
#apoptosis
#metabolism
|
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0
|
|
TIM3-targeted delivery of venetoclax overcomes drug resistance and reinvigorates NK cell activity in acute myeloid leukemia.
(nature.com)
|
Wang Q
…
Qian P
Nature Cancer
2026-08-12
|
#leukemia
#immunotherapy
#amr
#transcriptomics
#nanoparticles
|
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0
|
|
Mutant p53 reactivation and DNA demethylation in the treatment of AML/MDS.
(science.org)
|
Song H
…
Lu M
Science Translational Medicine
2026-08-12
|
#leukemia
#p53
#methylation
#immunotherapy
#mutagenesis
|
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0
|
|
RNA terminal uridylyl transferases are druggable vulnerabilities in AML but are dispensable for normal hematopoiesis.
(science.org)
|
Mapperley C
…
Kranc KR
Science Advances
2026-08-12
|
#leukemia
#hematopoiesis
#drug target
#apoptosis
|
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0
|
|
MBNL1 hijacks a structured single-stranded distal DNA element to sustain FLT3 expression in KMT2A-rearranged leukemias.
(science.org)
|
Che M
…
Li C
Science Advances
2026-08-07
|
#leukemia
#transcriptional-regulation
#dna-binding
#oncogene
|
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0
|
|
Dasatinib reversibly disrupts T cell motility and activation in lymph nodes.
(science.org)
|
Carvoeiro DC
…
Stein JV
Science Advances
2026-08-05
|
#immunology
#lymphocyte
#tyrosine kinase inhibitor
#leukemia
#cell-motility
|
|
0
|
|
Targeting oncogenic FLT3 uncovers a ferroptosis vulnerability through selenocysteine recoding in acute myeloid leukaemia.
(nature.com)
|
Li M
…
Nakada D
Nature Cell Biology
2026-08-01
|
#ferroptosis
#leukemia
#selenoprotein
#tyrosine-kinase-inhibitors
#drug resistance
|
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0
|
|
Tunable universal OR-gated CAR T cells for AML.
(linkinghub.elsevier.com)
|
Siddiqui MY
…
Wong WW
iScience
2026-08-04
|
#car-t
#leukemia
#immunotherapy
#synthetic biology
#antigen
|
|
0
|
|
Liposomal amphotericin B retrospective multicentre study on mycosis prophylaxis (L-AmB_RUSCO): tolerability and safety of extended-dosing primary antifungal prophylaxis in children with newly diagnosed acute myeloid leukaemia.
(academic.oup.com)
|
Ricci E
…
Castagnola E
Journal of Antimicrobial Chemotherapy
2026-08-04
|
#antifungal
#prophylaxis
#leukemia
#pediatric
#toxicity
|
|
0
|
|
ZMAT3 alleviates cell death in Fanconi anemia via adaptation of sphingolipid metabolism.
(science.org)
|
Loock M
…
Bluteau D
Science Advances
2026-07-31
|
#fanconi-anemia
#ferroptosis
#lipidomics
#transcriptomics
#leukemia
|
|
0
|
|
Analysis of cancer mutations introduced into the Drosophila melanogaster Notch negative regulatory region uncovers a diversity of regulatory outcomes.
(elifesciences.org)
|
Shimizu H
…
Baron M
eLife
2026-08-04
|
#oncogene
#signaling
#leukemia
#mutagenesis
|