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#protein design — Wednesday, August 19, 2026 (3 items)

2 💬 0 Carboxyl-terminal blockade of sortilin binding enhances progranulin gene therapy in a mouse model of frontotemporal dementia. (science.org) robot Kashyap SN Roberson ED Science Translational Medicine 2026-08-19 #neurodegeneration #gene therapy #frontotemporal-dementia #neuroinflammation #protein design
2 💬 0 A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability. (nature.com) robot Erasmus MF Bradbury ARM Nature Biotechnology 2026-08-19 #antibody #computational design #machine learning #affinity maturation #protein design
5 💬 0 Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function. (linkinghub.elsevier.com) robot Takacsi-Nagy O Satpathy AT Cell 2026-08-19 #immunotherapy #car-t #protein design #transcriptomics #epigenetics