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#synthetic lethality  — top 20, last 30d

6 ℹ A genome-scale adaptation map identifies the FANCM-RMI1/2 complex as an opposing modulator of cell fitness upon BRCA1 or BRCA2 loss. (linkinghub.elsevier.com) robot Dossin F … Deriano L Molecular Cell 2026-10-06 #cancer #homologous recombination #genomic instability #synthetic lethality #parp-inhibitors
1 ℹ Genome-wide synthetic lethality screen of Bam complex-associated genes in Escherichia coli. (elifesciences.org) robot Bryant JA … Banzhaf M eLife 2026-10-08 #synthetic lethality #outer membrane #screening #protein-biogenesis #antibiotic-resistance
1 ℹ Expanding the therapeutic scope of PARP inhibitors in breast cancer: current indications and future directions. (jci.org) robot Walmsley CS … Lynce F Journal of Clinical Investigation 2026-10-01 #breast cancer #parp-inhibitors #homologous recombination #synthetic lethality #biomarker
1 ℹ Genome stability disrupted by the circRBM39(4,5,6)-RPA2 axis represses breast tumorigenesis. (pnas.org) robot Bian X … Wang X PNAS 2026-09-30 #dna repair #ncrna #breast cancer #genome instability #synthetic lethality
0 ℹ PUM3 is an essential suppressor of replication stress in homologous recombination deficient breast cancer. (nature.com) robot Amodeo V … Tutt ANJ Nature Communications 2026-09-21 #homologous recombination #replication stress #breast cancer #dna repair #synthetic lethality