#synthetic lethality — top 20, last 14d
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A genome-scale adaptation map identifies the FANCM-RMI1/2 complex as an opposing modulator of cell fitness upon BRCA1 or BRCA2 loss.
(linkinghub.elsevier.com)
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Molecular Cell 2026-10-06 | #cancer #homologous recombination #genomic instability #synthetic lethality #parp-inhibitors | |
| 1 | ℹ |
Genome-wide synthetic lethality screen of Bam complex-associated genes in Escherichia coli.
(elifesciences.org)
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eLife 2026-10-08 | #synthetic lethality #outer membrane #screening #protein-biogenesis #antibiotic-resistance | |
| 1 | ℹ |
Expanding the therapeutic scope of PARP inhibitors in breast cancer: current indications and future directions.
(jci.org)
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Journal of Clinical Investigation 2026-10-01 | #breast cancer #parp-inhibitors #homologous recombination #synthetic lethality #biomarker | |
| 1 | ℹ |
Genome stability disrupted by the circRBM39(4,5,6)-RPA2 axis represses breast tumorigenesis.
(pnas.org)
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PNAS 2026-09-30 | #dna repair #ncrna #breast cancer #genome instability #synthetic lethality |