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12
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A pro-natural product design strategy affords ester-based green fungicide candidates.
(science.org)
|
Lei P
…
Liu X
Science Advances
2026-08-26
|
#fungicide
#natural products
#agrochemical
#antifungal
#drug discovery
|
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4
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Hepatocellular carcinoma organoids enable drug discovery and combination therapy across heterogeneous tumors.
(linkinghub.elsevier.com)
|
Nuciforo S
…
Heim MH
Cell Reports
2026-08-24
|
#organoid
#hepatocellular carcinoma
#drug discovery
#combination therapy
#heterogeneity
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2
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Searching the Druggable Genome using Large Language Models.
(academic.oup.com)
|
Schimmelpfennig L
…
Griffith OL
Bioinformatics
2026-08-22
|
#pharmacogenomics
#drug discovery
#bioinformatics
#machine learning
|
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2
|
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GRASSP: RNA Language Model-Enhanced Graph Attention with Adaptive Gating for RNA-Small Molecule Binding Site Prediction.
(academic.oup.com)
|
Nguyen TL
…
Quoc Khanh Le N
Bioinformatics
2026-08-22
|
#rna
#binding
#drug discovery
#machine learning
#structure prediction
|
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2
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Targeting PKGIalpha Cys(42) attenuates cardiac dysfunction in heart failure with preserved ejection fraction.
(science.org)
|
Su J
…
Burgoyne JR
Science Advances
2026-08-19
|
#heart failure
#diastolic-dysfunction
#cardiac remodeling
#protein modification
#drug discovery
|
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1
|
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Identification of potent inhibitors of JUN N-terminal kinases for treatment of endometriosis and associated pain.
(pnas.org)
|
Madasu C
…
Monsivais D
PNAS
2026-08-19
|
#endometriosis
#inhibitor
#inflammation
#drug discovery
#kinase
|
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1
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|
The application and progress of AI-based image analysis in tumor organoid research.
(linkinghub.elsevier.com)
|
Xu Y
…
Dong L
iScience
2026-08-21
|
#organoid
#cancer
#imaging
#deep learning
#drug discovery
|
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0
|
|
iHaptenAb: an integrated hapten-antibody database for rational hapten design and antibody discovery.
(academic.oup.com)
|
Wu W
…
Wang Z
Nucleic Acids Research
2026-08-13
|
#antibody
#immunoassay
#hapten
#database
#drug discovery
|
|
0
|
|
Proteome-wide identification of the druggable CRBN interactome.
(nature.com)
|
Galli P
…
Thoma NH
Nature Biotechnology
2026-08-13
|
#proteomics
#protein-interactions
#ubiquitin-ligase
#drug discovery
#degradation
|
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0
|
|
Discovery of antimicrobial peptides from incomplete biosynthetic gene clusters to combat multidrug-resistant bacteria.
(linkinghub.elsevier.com)
|
Tang Y
…
Chen Q
Cell Reports Medicine
2026-08-12
|
#antimicrobial peptides
#amr
#biosynthesis
#drug discovery
#genomics
|
|
0
|
|
M2-PRNet: Multi-Scale and Multi-Modal Learning for Protein-RNA Binding Affinity Prediction.
(academic.oup.com)
|
Wang J
…
Li M
Bioinformatics
2026-08-14
|
#protein-rna
#binding
#machine learning
#structure prediction
#drug discovery
|
|
0
|
|
Bronsted-basic small molecules activate GTP hydrolysis in KRAS-Q61 mutants.
(nature.com)
|
Wang YC
…
Zhang Z
Nature Chemical Biology
2026-08-12
|
#oncology
#kras
#inhibitor
#gtpase
#drug discovery
|
|
0
|
|
Cryptic small-molecule binding sites in the ARID1B DNA-binding domain.
(pnas.org)
|
Carbone CE
…
Holliday MJ
PNAS
2026-08-12
|
#drug discovery
#cancer
#protein structure
#simulation
#nmr
|
|
0
|
|
Structure-Agnostic Protein-Ligand Binding Affinity Prediction via Hierarchical Representation Alignment.
(academic.oup.com)
|
Hu X
…
Deng L
Bioinformatics
2026-08-10
|
#binding
#machine learning
#protein design
#drug discovery
|
|
0
|
|
A Unified Framework for Molecular Property Prediction based on Hierarchical Multi-Granularity Molecular Representation Learning.
(academic.oup.com)
|
Zhao X
…
Zhao H
Bioinformatics
2026-08-10
|
#molecular
#prediction
#representation
#drug discovery
|
|
0
|
|
Identification of SKI-II as a host-protective immunomodulator against Staphylococcus aureus infection.
(journals.asm.org)
|
Zhang L
…
Mylonakis E
mBio
2026-08-10
|
#immunomodulation
#infection
#host-directed therapy
#drug discovery
#macrophage
|
|
0
|
|
Artificial intelligence in drug discovery - what it is, where we stand and the path forward.
(nature.com)
|
Bender A
…
Cortes-Ciriano I
Nature Reviews Drug Discovery
2026-08-07
|
#drug discovery
#ai
#computational
#translation
|
|
0
|
|
DCAF11-dependent molecular glue degrader activated by glutathionylation.
(nature.com)
|
Yoon H
…
Ebert BL
Nature
2026-08-05
|
#proteolysis
#ubiquitination
#protein degradation
#drug discovery
#chemical-screening
|
|
0
|
|
MOZAIC: Compound Growth via In Silico Reactions and Global Optimization using Conformational Space Annealing.
(academic.oup.com)
|
Yoo J
…
Shin WH
Bioinformatics
2026-08-07
|
#drug discovery
#computational chemistry
#molecular-optimization
#synthetic-accessibility
|
|
0
|
|
Drug Target Prediction from Perturbation Transcriptomics via a Biological Function-Guided Hypergraph Siamese Network.
(academic.oup.com)
|
Zhang X
…
Li M
Bioinformatics
2026-08-06
|
#transcriptomics
#drug discovery
#target prediction
#machine learning
#perturbation
|