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5
|
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Proteome-guided drug discovery maps and mitigates therapeutic degrader toxicity.
(nature.com)
|
Basu S
…
Ralser M
Nature Chemical Biology
2026-10-09
|
#proteomics
#degraders
#toxicity
#drug discovery
#cancer
|
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2
|
|
Large-scale prospective evaluation of co-folding across hundreds of Mac1-ligand complexes and three virtual screens.
(elifesciences.org)
|
Kim J
…
Fraser JS
eLife
2026-10-12
|
#drug discovery
#structure prediction
#deep learning
#affinity
#docking
|
|
2
|
|
ProDTI: Prior-Guided Positive-Unlabeled Learning for Robust Drug-Target Interaction Prediction.
(academic.oup.com)
|
Wang Y
…
Li Y
Bioinformatics
2026-10-07
|
#machine learning
#drug discovery
#deep learning
#protein-protein interaction
#computational biology
|
|
1
|
|
Multiobjective V(H)H discovery through integrated high-throughput screening and AlphaFold3-guided structural prioritization.
(science.org)
|
Overath MD
…
Jenkins TP
Science Advances
2026-10-02
|
#antibody
#screening
#toxins
#structure prediction
#drug discovery
|
|
1
|
|
Predicting and finding geroprotective compounds through modulating conserved longevity-associated aging modules.
(science.org)
|
Huai W
…
Gruber J
Science Advances
2026-10-02
|
#transcriptomics
#aging
#longevity
#drug discovery
#coexpression
|
|
1
|
|
Screening of a chemogenetic library unveils dual-stage antiplasmodials with low cytotoxicity.
(journals.asm.org)
|
Torres L
…
Mitchell G
Antimicrobial Agents and Chemotherapy
2026-10-05
|
#malaria
#drug discovery
#screening
#antiparasitic
#parasitology
|
|
0
|
|
Development of A10P3C, an isoform-selective inhibitor of EGLN2, for targeting breast cancer.
(pnas.org)
|
Liang Q
…
Zhang Q
PNAS
2026-10-01
|
#cancer
#inhibitor
#drug discovery
#transcriptomics
#selectivity
|
|
0
|
|
A small molecule increases mycobacterial translation fidelity without a fitness cost by targeting ribosomal protein S5.
(journals.asm.org)
|
Wu J
…
Javid B
mBio
2026-10-02
|
#tb
#antibiotic-resistance
#translation
#drug discovery
#ribosome
|
|
0
|
|
Positive selection screen identifies natural product beta-catenin inactivators.
(pnas.org)
|
Boudreau MW
…
Kaelin WG Jr
PNAS
2026-09-29
|
#screening
#natural products
#cancer
#drug discovery
#protein degradation
|
|
0
|
|
GCF-anchored and target-oriented mining of metagenomic BGC space for bioactive product discovery.
(journals.asm.org)
|
Yang X
…
Zhang L
Microbiology Spectrum
2026-10-01
|
#metagenomics
#biosynthesis
#drug discovery
#natural products
#cytotoxicity
|
|
0
|
|
Targeting an atypical G protein-coupled receptor signaling pathway for cardiac fibrosis therapy.
(science.org)
|
Zhang H
…
Wu JC
Science
2026-09-24
|
#fibrosis
#cardiology
#signaling
#drug discovery
#stem-cells
|
|
0
|
|
The evolving landscape of drug targets.
(nature.com)
|
Halip L
…
Oprea TI
Nature Reviews Drug Discovery
2026-09-21
|
#drug discovery
#druggability
#therapeutics
#proteomics
|
|
0
|
|
Dynamic Fourier wavelet positional encoding for anticancer peptide prediction via transfer learning.
(linkinghub.elsevier.com)
|
You G
…
Li J
iScience
2026-09-24
|
#cancer
#peptide
#prediction
#machine learning
#drug discovery
|
|
0
|
|
Multiscale cross modal fusion and cascaded signal propagation for drug target interaction prediction.
(linkinghub.elsevier.com)
|
Wang B
…
Peng S
iScience
2026-09-22
|
#drug-target interaction
#deep learning
#protein-embeddings
#drug discovery
#virtual screening
|
|
0
|
|
The Virtual Biotech: A multi-agent AI framework for therapeutic discovery and development.
(science.org)
|
Zhang HG
…
Zou J
Science
2026-09-17
|
#drug discovery
#therapeutic-development
#ai
#clinical-trials
#target-selection
|
|
0
|
|
HD-AIP: A Heterogeneous Dual-Stream Alignment-Free Framework for Anti-Inflammatory Peptide Prediction Based on Language Models and CT-Net.
(academic.oup.com)
|
Li J
…
Niu M
Bioinformatics
2026-09-21
|
#deep learning
#peptide
#prediction
#immunology
#drug discovery
|
|
0
|
|
Combating antimicrobial resistance through multimodal data via artificial intelligence.
(linkinghub.elsevier.com)
|
Xia Q
…
Wu X
One Health
2026-09-20
|
#amr
#ai
#machine learning
#diagnostics
#drug discovery
|
|
0
|
|
Structure-based design of subtype-selective psychedelic analogs.
(nature.com)
|
Li H
…
Cheng J
Nature Communications
2026-09-17
|
#psychedelics
#cryo-em
#drug discovery
#structure_based_design
#selectivity
|
|
0
|
|
Development of a random background to understand ligand optimization.
(nature.com)
|
Xu X
…
Shoichet BK
Nature
2026-09-16
|
#drug discovery
#ligand-optimization
#medicinal chemistry
#structure-activity relationship
|
|
0
|
|
A scalable, high-throughput glue perturbation screening platform for molecular glue discovery.
(linkinghub.elsevier.com)
|
Huang D
…
Wu W
iScience
2026-09-19
|
#screening
#transcriptomics
#degradation
#high-throughput
#drug discovery
|