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0
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An integrative transcriptomic atlas of ALS and aging skeletal muscle defines shared and distinct molecular programs of degeneration.
(pnas.org)
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Grima-Terren M
…
Munoz-Canoves P
PNAS
2026-10-15
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#transcriptomics
#neurodegeneration
#aging
#sarcopenia
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0
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Ataxin-2 downregulation rewires neuronal and astrocytic metabolism to protect against TDP-43 toxicity.
(linkinghub.elsevier.com)
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Gastaldo D
…
Jovicic A
Cell Reports
2026-10-15
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#proteomics
#metabolism
#neurodegeneration
#neuroprotection
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1
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Edited HSPCs rescue frataxin deficiency and inflammation-driven multisystemic pathology in Friedreich's ataxia mice.
(jci.org)
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Sivakumar A
…
Cherqui S
Journal of Clinical Investigation
2026-10-15
|
#crispr
#gene therapy
#mitochondrial
#neurodegeneration
#inflammation
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1
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Genome-wide CRISPR screen reveals that Wnt signaling regulates lipid accumulation in APOE4 oligodendrocytes.
(linkinghub.elsevier.com)
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Akay LA
…
Tsai LH
Cell Stem Cell
2026-10-15
|
#crispr
#neurodegeneration
#myelination
#lipid
#signaling
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1
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Escherichia coli hns and methylglyoxal link gut microbial metabolism to host neuronal gene regulation in Parkinson's disease.
(tandfonline.com)
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Shin MG
…
Lee EJ
Gut Microbes
2026-10-15
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#microbiome
#neurodegeneration
#metabolism
#transcriptomics
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1
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Modeling human neurodegeneration with iPSCs: opportunities, limitations, and the challenge of aging.
(jci.org)
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Wang S
…
Finkbeiner S
Journal of Clinical Investigation
2026-10-15
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#neurodegeneration
#ipscs
#aging
#organoid
#epigenetics
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