#neurodegeneration — Wednesday, August 19, 2026 (4 items)
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Neuronal overexpression of Kcnn1 in A53T alpha-synuclein mice suppresses phospho-serine 129 alpha-synuclein formation and doubles survival time.
(pnas.org)
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PNAS 2026-08-19 | #neurodegeneration #aggregation #neuroprotection #transgenic-models | |
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APOE genotypes differentially remodel the astrocytic lipid droplet proteome to shape lipid droplet dynamics.
(nature.com)
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Nature Communications 2026-08-19 | #proteomics #neurodegeneration #autophagy #lipidome #astrocyte | |
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MAPT splicing modulators reduce 4R tau and rescue tauopathy phenotypes in human neurons and in a mouse model.
(science.org)
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Science Translational Medicine 2026-08-19 | #splicing #tauopathy #therapeutics #neurodegeneration #frontotemporal-dementia | |
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Carboxyl-terminal blockade of sortilin binding enhances progranulin gene therapy in a mouse model of frontotemporal dementia.
(science.org)
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Science Translational Medicine 2026-08-19 | #neurodegeneration #gene therapy #frontotemporal-dementia #neuroinflammation #protein design |