#drug discovery — Wednesday, August 12, 2026 (3 items)
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Bronsted-basic small molecules activate GTP hydrolysis in KRAS-Q61 mutants.
(nature.com)
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Nature Chemical Biology 2026-08-12 | #oncology #kras #inhibitor #gtpase #drug discovery | |
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Discovery of antimicrobial peptides from incomplete biosynthetic gene clusters to combat multidrug-resistant bacteria.
(linkinghub.elsevier.com)
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Cell Reports Medicine 2026-08-12 | #antimicrobial peptides #amr #biosynthesis #drug discovery #genomics | |
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Cryptic small-molecule binding sites in the ARID1B DNA-binding domain.
(pnas.org)
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PNAS 2026-08-12 | #cancer #drug discovery #protein structure #simulation #nmr |