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#cancer — Tuesday, April 21, 2026 (26 items)

0 💬 0 Impact of chronic low-dose external gamma- and internal tritium beta-irradiation on the gut microbiome in the context of intestinal tumorigenesis in Apc(Min/+) mice. (journals.asm.org) robot Laakso H Klokov D mSystems 2026-04-21 #microbiome #dysbiosis #cancer #sequencing #inflammation
0 💬 0 Type I interferons induced upon respiratory viral infection impair lung metastatic initiation. (pnas.org) robot Farias A Johansson C PNAS 2026-04-21 #metastasis #interferon #immunity #infection #cancer
0 💬 0 SpaNiche: spatial niche analysis to explore colocalization patterns and cellular interactions in spatial transcriptomics data. (link.springer.com) robot Huang S Xi R Genome Biology 2026-04-21 #transcriptomics #clustering #interaction #cancer
0 💬 0 WWOX maintains epidermal identity and suppresses EMT to prevent aggressive cutaneous squamous cell carcinoma. (pnas.org) robot Bidany-Mizrahi T Aqeilan RI PNAS 2026-04-21 #cancer #emt #virulence #transcriptomics
0 💬 0 Development and validation of a 5mC-based prognostic model for lung adenocarcinoma survival. (linkinghub.elsevier.com) robot Wu Y Chen Q Cell Reports Medicine 2026-04-21 #methylation #prognosis #cancer #modeling #biomarker
0 💬 0 Early-stage multi-cancer detection through a plasma extracellular vesicle protein signature. (linkinghub.elsevier.com) robot Lobb RJ Moller A Cell Reports Medicine 2026-04-21 #biomarker #proteomics #cancer #diagnostics #extracellular vesicles
0 💬 0 The microbial metabolome: remodeling the therapeutic landscape in hematologic malignancies. (nature.com) robot Zhang L Gafarov R npj Biofilms and Microbiomes 2026-04-21 #microbiome #metabolism #cancer #immunotherapy #chemotherapy
0 💬 0 Immunogenic tumor cell death and T-cell-derived IFN-gamma elicit tumoricidal macrophages to potentiate OX40 immunotherapy. (linkinghub.elsevier.com) robot Liu Y Zhang H Cell Reports Medicine 2026-04-21 #immunotherapy #macrophage #tumor microenvironment #cancer #immunity
0 💬 0 Combination immunotherapy for colorectal cancer: Clinical applications, rationale, challenges, and future perspectives. (linkinghub.elsevier.com) robot Fei J Zeng S Cell Reports Medicine 2026-04-21 #immunotherapy #cancer #tme #biomarker
0 💬 0 A senescent tumor cell-derived nanovesicle directly primes splenic T cells to potentiate cancer radiotherapy. (linkinghub.elsevier.com) robot Pan J Lai Y Cell Reports Medicine 2026-04-21 #immunotherapy #senescence #nanovesicles #cancer #immunity
0 💬 0 Histone methyl-transferase G9a inhibition boosts the efficacy of immune checkpoint inhibitors in experimental hepatocellular carcinoma. (linkinghub.elsevier.com) robot Adan-Villaescusa E Fernandez-Barrena MG Cell Reports Medicine 2026-04-21 #immunotherapy #cancer #epigenetics #immunity #hepatocellular carcinoma
0 💬 0 A harmless-to-harmful switchable and spatiotemporally activated nano-CRISPR hierarchically amplifies ferroptosis in melanoma. (linkinghub.elsevier.com) robot Ou C Gong C Cell Reports Medicine 2026-04-21 #ferroptosis #crispr #cancer #nanoparticles #ros
0 💬 0 Single-cell analysis highlights the significance of malignant cell IFN/MHC-II for immunotherapy response in head and neck squamous cell carcinoma. (linkinghub.elsevier.com) robot Mints M Puram SV Cell Reports Medicine 2026-04-21 #transcriptomics #immunotherapy #cancer #immunity #biomarker
0 💬 0 Robust transcriptomic hallmarks targeting intratumor heterogeneity in intrahepatic cholangiocarcinoma. (linkinghub.elsevier.com) robot Lin Y Fan J Cell Reports Medicine 2026-04-21 #transcriptomics #heterogeneity #cancer #immunotherapy #biomarker
0 💬 0 HE4 drives PD-L1 expression in myeloid cells via IFN-gammaR-JAK-STAT3 signaling to promote tumor immune evasion. (linkinghub.elsevier.com) robot Zeng B Wang C Cell Reports Medicine 2026-04-21 #immunotherapy #checkpoint #signaling #biomarker #cancer
0 💬 0 Targeting TPX2-dependent lineage plasticity by CDK4/6 inhibition reverses therapy resistance in neuroendocrine bladder carcinoma. (linkinghub.elsevier.com) robot Chen Z Chen X Cell Reports Medicine 2026-04-21 #transcriptomics #cancer #immunity #plasticity
0 💬 0 A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer. (linkinghub.elsevier.com) robot Ning W Luo W Cell Reports Medicine 2026-04-21 #immunotherapy #cancer #antibody #therapeutics #cytotoxicity
0 💬 0 mRNA lipid-nanoparticle-mediated mitochondrial apoptosis augments adoptive T cell immunotherapy. (linkinghub.elsevier.com) robot Fu J Jin Y Cell Reports Medicine 2026-04-21 #immunotherapy #apoptosis #transcriptomics #cancer #rna
0 💬 0 Single-cell spatial transcriptomics reveals tumor microenvironment heterogeneity in primary and lymph node-metastatic small cell lung cancer. (linkinghub.elsevier.com) robot Zhang Z Zhou M Cell Reports Medicine 2026-04-21 #transcriptomics #microenvironment #cancer #immunity
0 💬 0 Self-adjuvanting alpha-helical polypeptide simultaneously delivers neoantigen mRNAs and activates dendritic cells to eradicate tumors. (pnas.org) robot Han J Wang H PNAS 2026-04-21 #dendritic cell #vaccination #immunotherapy #neoantigen #cancer
0 💬 0 Profile of Helen M. Piwnica-Worms. (pnas.org) robot Williams SCP PNAS 2026-04-21 #amr #cancer #cell cycle #modeling
0 💬 0 Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumors. (linkinghub.elsevier.com) robot Cao Y Qiao Y Cell Reports Medicine 2026-04-21 #metabolism #cancer #autophagy #lysosome #amr
0 💬 0 Out-of-frame CBX3::ALK fusion drives ALK activation and therapy response. (linkinghub.elsevier.com) robot Hang JF Yang MH Cell Reports Medicine 2026-04-21 #fusion #cancer #oncology #sequencing #kinase
0 💬 0 Engineered oncolytic virus armed with anti-PCSK9 scFv boosts long-term CD8(+) T cell immunity via rewiring MHC-I antigen presentation. (linkinghub.elsevier.com) robot Feng H Xing F Cell Reports Medicine 2026-04-21 #immunotherapy #oncolytic #cancer #immunity #engineering
0 💬 0 Spatial multi-omics unveils the monoclonal origin, neuroendocrine plasticity, and microenvironment niches in combined small-cell lung cancer. (linkinghub.elsevier.com) robot Wang Z Li Z Cell Reports Medicine 2026-04-21 #heterogeneity #plasticity #microenvironment #cancer #spatial omics
0 💬 0 Targeting the noncanonical function of metabolic enzyme PHGDH in driving PD-L1 expression and cancer immune evasion. (linkinghub.elsevier.com) robot Liu J Feng Z Cell Reports Medicine 2026-04-21 #cancer #immunity #metabolism #signaling