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#cancer — Tuesday, January 20, 2026 (19 items)

0 💬 0 c-JUN enhances CRISPR knockin anti-B7-H3 CAR T cell function in small cell lung cancer and thoracic SMARCA4-deficient undifferentiated tumors. (linkinghub.elsevier.com) robot Balke-Want H Feldman SA Cell Reports Medicine 2026-01-20 #cancer #immunotherapy #crispr #car-t #cytotoxicity
0 💬 0 Targeting TCF21-TCF3 heterodimer in tumor-associated pericytes attenuates hematogenous metastasis by restoring pericyte gatekeeper function. (linkinghub.elsevier.com) robot Yin W Zhang D Cell Reports Medicine 2026-01-20 #cancer #therapeutics #metastasis #vascular #pericyte
0 💬 0 UniCAS: A foundation model for cervical cytology screening. (linkinghub.elsevier.com) robot Jiang H Wang Q Cell Reports Medicine 2026-01-20 #cancer #screening #deep learning #pathology #cytology
0 💬 0 CAR-T triggers TAM reeducation and adaptive anti-tumor response via TREM2 deficiency or CD40 agonist. (linkinghub.elsevier.com) robot Liu T Tan J Cell Reports Medicine 2026-01-20 #metabolism #cancer #immunotherapy #car-t #macrophage
0 💬 0 Targeting senescent EGR1(+) B cells enhances immunotherapy efficacy in esophageal squamous cell carcinoma. (linkinghub.elsevier.com) robot Zhou P Gu J Cell Reports Medicine 2026-01-20 #immunity #cancer #inflammation #immunotherapy #senescence
0 💬 0 CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance. (linkinghub.elsevier.com) robot Watterson A Coelho MA Cell Reports Medicine 2026-01-20 #immunity #cancer #screening #immunotherapy #crispr
0 💬 0 zAvatar-test-A functional precision model to personalize ovarian cancer treatments: Results from a co-clinical study. (linkinghub.elsevier.com) robot Estrada MF Fior R Cell Reports Medicine 2026-01-20 #modeling #cancer #chemotherapy #personalization
0 💬 0 Multiomics identifies a cholesterol-TFEB-PLD3-TLR9 axis driving immunosuppressive tumor-associated macrophage polarization in esophageal squamous cell carcinoma. (pnas.org) robot Tan L Guan X PNAS 2026-01-20 #metabolism #immunosuppression #transcriptomics #cancer #macrophage
0 💬 0 Targeting severe acidity for tumor-activatable Interleukin-2 therapy. (linkinghub.elsevier.com) robot Feng Q Gao J Cell Reports Medicine 2026-01-20 #nanoparticles #cancer #immunotherapy #cytokine #prodrug
0 💬 0 An innovative engineered IL-10 monomer strengthens T cell-mediated anti-tumor responses through anti-PD-1 cis-delivery. (linkinghub.elsevier.com) robot Gu C Lu D Cell Reports Medicine 2026-01-20 #cancer #immunotherapy #cytokine #checkpoint #exhaustion
0 💬 0 Mutational landscape of normal breast tissues adjacent to invasive breast cancer. (linkinghub.elsevier.com) robot Suwalska A Pusztai L Cell Reports Medicine 2026-01-20 #cancer #sequencing #mutation #germline
0 💬 0 Microbial-derived immunostimulatory small molecule augments anti-PD-1 therapy in lung cancer. (linkinghub.elsevier.com) robot Newsome RC Jobin C Cell Reports Medicine 2026-01-20 #microbiome #metabolism #immunity #cancer #immunotherapy
0 💬 0 Engineered Akkermansia muciniphila vesicles for targeted pyroptosis and trained immunity to enhance immunotherapy in hepatocellular carcinoma. (linkinghub.elsevier.com) robot Huang L Wang F Cell Reports Medicine 2026-01-20 #nanoparticles #immunity #cancer #immunotherapy #pyroptosis
0 💬 0 Multimodal profiling of pancreatic cancer reveals a TIMP-1-dominated secretory profile determining pro-tumor immunoinstruction in human cancers. (linkinghub.elsevier.com) robot Fradrich J Kruger A Cell Reports Medicine 2026-01-20 #proteomics #immunosuppression #immunity #transcriptomics #cancer
0 💬 0 DF6215, an alpha-optimized IL-2-Fc fusion, expands immune effectors and drives robust preclinical anti-tumor activity. (linkinghub.elsevier.com) robot Stockmann AP Cheung AF Cell Reports Medicine 2026-01-20 #immunity #cancer #immunotherapy #cytokine #protein design
0 💬 0 Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer. (linkinghub.elsevier.com) robot Zhan W Deng Y Cell Reports Medicine 2026-01-20 #virulence #immunity #cancer #immunotherapy #proteolysis
0 💬 0 Macrophage efferocytosis mediated by the TP63-RAC2 pathway promotes immunosuppressive remodeling in esophageal cancer. (linkinghub.elsevier.com) robot Xi Y Shen W Cell Reports Medicine 2026-01-20 #immunity #transcriptomics #cancer #macrophage #efferocytosis
0 💬 0 Proteasomal proteolysis in p62 condensates directs tumor suppression or growth depending on their subcellular localization. (pnas.org) robot Lulu-Shimron C Ciechanover A PNAS 2026-01-20 #cancer #phase separation #autophagy #proteolysis #ubiquitin
0 💬 0 The best from both disciplines: integrating human and microbial signatures from whole genome sequencing to advance cancer diagnostics. (journals.asm.org) robot Moser T Mahnert A mSystems 2026-01-20 #microbiome #metagenomics #cancer #sequencing #machine learning