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#protein degradation  — top 20, last 30d

0 💬 0 Programmable DNA hydrogels for dual-mode PD-L1 suppression via polyvalent LYTAC mimics and transcriptional silencing. (pnas.org) robot Zhang R … Yang D PNAS 2026-06-16 #immunotherapy #cancer #dna nanotechnology #gene silencing #protein degradation
0 💬 0 Mechanisms of ubiquitylation of the mitotic regulatory protein Cdc20. (pnas.org) robot Sitry-Shevah D … Hershko A PNAS 2026-06-16 #ubiquitylation #mitosis #proteolysis #protein degradation
0 💬 0 Giredestrant immobilizes the estrogen receptor to exert potent antitumor efficacy against ER-active breast cancers. (linkinghub.elsevier.com) robot Zhou W … Metcalfe C Cell Chemical Biology 2026-06-18 #breast cancer #drug development #estrogen receptor #protein degradation #endocrinology
0 💬 0 Ubiquitin-dependent degradation of p27Kip1 and p21Waf1/Cip1 by AMBRA1 ensures G1 and S phase progression and limits replication stress. (academic.oup.com) robot Milletti G … Cecconi F Nucleic Acids Research 2026-06-22 #ubiquitination #cell cycle #medulloblastoma #replication stress #protein degradation
0 💬 0 Lysine methylation as a bidirectional switch. (linkinghub.elsevier.com) robot Gia Le BQ … Raj M Cell Chemical Biology 2026-06-24 #methylation #protein degradation #proteomics #ubiquitin #post-translational-modification
0 💬 0 Cytoplasmic lattices store developmentally poised degradative and cytoskeletal complexes in mammalian eggs. (nature.com) robot Li Y … Xiong Y Nature Structural & Molecular Biology 2026-07-09 #embryogenesis #cryo-em #ubiquitination #cytoskeleton #protein degradation