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#protein degradation
— top 20, last 30d
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Positive selection screen identifies natural product beta-catenin inactivators.
(pnas.org)
Boudreau MW
…
Kaelin WG Jr
PNAS
2026-09-29
#screening
#natural products
#cancer
#drug discovery
#protein degradation
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DesignMaster: A Multi-Conditional Diffusion Framework for Rational PROTAC Design.
(academic.oup.com)
Shi B
…
Li F
Bioinformatics
2026-09-24
#protein degradation
#drug design
#generative_models
#molecular_generation
#computational chemistry
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Inflammatory memory inactivates AMPK-stimulated DDR1 degradation to enable pancreatic cancer growth.
(pnas.org)
Yang F
…
Su H
PNAS
2026-09-22
#pancreatic cancer
#metabolism
#inflammation
#signaling
#protein degradation
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Photomorphogenesis: A molecular brake on PIF4.
(linkinghub.elsevier.com)
Mitra O
…
Huq E
Current Biology
2026-09-21
#ubiquitination
#photomorphogenesis
#protein degradation
#signal transduction
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Ubiquitin receptor-mediated, ubiquitin-independent targeted protein degradation via 26S proteasomes.
(science.org)
Park SH
…
Lee MJ
Science Advances
2026-09-18
#protein degradation
#proteolysis
#proteasome
#ubiquitin
#therapeutics