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16
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UBT251, a novel triple GLP-1, GIP, and glucagon receptor agonist, in adults with overweight or obesity: A multicenter, randomized phase 2 trial.
(linkinghub.elsevier.com)
|
Zhou Z
…
Yan H
Cell Metabolism
2026-10-07
|
#clinical trial
#obesity
#metabolic
#pharmacology
#cardiovascular
|
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10
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Metabolic benefits of ketohexokinase inhibition in individuals with MASLD: a randomized placebo-controlled crossover trial.
(nature.com)
|
Koene EJC
…
Brouwers MCGJ
Nature Metabolism
2026-10-07
|
#steatosis
#metabolism
#lipidmetabolism
#pharmacology
|
|
6
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Mechanisms of intracellular pH gating and local anesthetic inhibition of the two-pore domain K(+) channel TASK-2.
(pnas.org)
|
Docter T
…
Brohawn SG
PNAS
2026-10-08
|
#ion channel
#electrophysiology
#cryo-em
#gating
#pharmacology
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2
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|
Serotonin biology as a basis for explaining psychedelic drug action.
(linkinghub.elsevier.com)
|
Knox CA
…
Kwan AC
Current Biology
2026-10-05
|
#psychedelics
#serotonin
#pharmacology
#receptor
#neuropharmacology
|
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2
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Structural and kinetic mechanisms of state-dependent potassium channel inhibition.
(science.org)
|
Kyriakis E
…
Fedida D
Science Advances
2026-10-02
|
#cryo-em
#channels
#pharmacology
#allosteric
#arrhythmia
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1
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Molecular glue everywhere: Metabolites join the party.
(linkinghub.elsevier.com)
|
Wang B
…
Zheng N
Molecular Cell
2026-10-01
|
#metabolism
#protein-protein interaction
#nucleotides
#pharmacology
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0
|
|
GLP-1 receptor agonist exposure in the periconceptional period and adverse obstetric outcomes: A systematic review and meta-analysis.
(linkinghub.elsevier.com)
|
D'Antonio F
…
Khalil A
Cell Med
2026-09-29
|
#meta-analysis
#pregnancy
#pharmacology
#obstetrics
#diabetes
|
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0
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|
Antimicrobials in a Box: A Primer on the Risks of Direct-to-Consumer Antimicrobial Preparedness Kits.
(academic.oup.com)
|
Kufel WD
…
Gallagher JC
Clinical Infectious Diseases
2026-09-29
|
#amr
#safety
#stewardship
#pharmacology
|
|
0
|
|
Spatiotemporal modeling of GPCR signaling: The role of endosomal dynamics and receptor recycling.
(journals.plos.org)
|
Weckel C
…
Yvinec R
PLOS Computational Biology
2026-09-29
|
#signaling
#trafficking
#modeling
#endosomes
#pharmacology
|
|
0
|
|
The nematode Caenorhabditis elegans has a cationic amphiphilic drug (CAD) defense system.
(journals.plos.org)
|
Tokmakjian L
…
Roy PJ
PLOS Biology
2026-09-21
|
#toxicology
#metabolism
#detoxification
#genetics
#pharmacology
|
|
0
|
|
Ga(III) ion release from gallium-based liquid metals: The trade-off between efficacy and safety.
(linkinghub.elsevier.com)
|
Wang D
…
Pan W
iScience
2026-09-21
|
#toxicology
#nanomedicine
#pharmacology
#biomaterials
#biodegradation
|
|
0
|
|
VCCV: conservative transcriptomic corroboration for measurement prioritization of computational drug-target hypotheses.
(academic.oup.com)
|
Huang H
…
Liang Y
Bioinformatics
2026-09-18
|
#transcriptomics
#drug target
#pharmacology
#computational
|
|
0
|
|
Efficacy of quabodepistat alone and in combination with delamanid and bedaquiline against Mycobacterium tuberculosis in an NHP model evaluated by [(18)F] FDG PET/CT and bacterial burden.
(journals.asm.org)
|
Via LE
…
Barry CE 3rd
Antimicrobial Agents and Chemotherapy
2026-09-16
|
#tb
#amr
#imaging
#drug combination
#pharmacology
|