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#pancreatic cancer
— top 20, last 30d
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Pancreatic cancer fibrosis activates protumorigenic Schwann cells through a nuclear mechanosensing mechanism.
(gut.bmj.com)
Stupakov P
…
Deborde S
Gut
2026-06-23
#pancreatic cancer
#fibrosis
#mechanotransduction
#tumor microenvironment
#innervation
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HDAC inhibition sensitizes pancreatic tumors to DNA damage by global redistribution of the transcriptional machinery.
(pnas.org)
Liang G
…
Evans RM
PNAS
2026-06-25
#epigenetics
#pancreatic cancer
#dna damage
#chemotherapy
#nanoparticles
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USP20 promotes CD8(+) T cell exhaustion and impairs KRAS(G12D) inhibitor efficacy by orchestrating cholesterol metabolism and autophagy in pancreatic cancer.
(gut.bmj.com)
Yu Z
…
Jiao Z
Gut
2026-07-02
#pancreatic cancer
#immunotherapy
#metabolism
#drug resistance
#single-cell sequencing
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Dysregulated sphingolipid metabolismdrives pancreatic carcinogenesis through plasma membrane Kras enrichment.
(gut.bmj.com)
Alnatsha A
…
Mahajan UM
Gut
2026-07-03
#pancreatic cancer
#sphingolipids
#metabolism
#carcinogenesis
#crispr
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Investigating the anticancer activity of eravacycline in pancreatic cancer via target-based deep learning and experimental validation.
(academic.oup.com)
Jabarin A
…
Ben-Shabat S
Briefings in Bioinformatics
2026-07-03
#pancreatic cancer
#drug discovery
#deep learning
#computational-screening
#p53
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KRAS-G12D inhibitor HRS-4642 plus chemotherapy in advanced KRAS(G12D)-mutant pancreatic cancer: a phase 1b/2 trial.
(nature.com)
Cui J
…
Wang L
Nature Medicine
2026-07-09
#oncology
#pancreatic cancer
#clinical trial
#targeted therapy
#chemotherapy