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12
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Adaptive model-guided protein evolution with sparse data optimizes compact eukaryotic genome editors.
(nature.com)
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Wan S
…
Gao X
Nature Biotechnology
2026-08-24
|
#protein design
#genome editing
#machine learning
#nucleases
#optimization
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1
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Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells.
(nature.com)
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Jung H
…
Carnevale J
Nature Biotechnology
2026-08-17
|
#crispr
#genome editing
#immunotherapy
#screening
#macrophage
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1
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RAD51 proximity mapping reveals spatial constraints on homology search during DNA double-stranded break repair.
(linkinghub.elsevier.com)
|
Yeh CD
…
Corn JE
Cell Reports
2026-08-17
|
#dna repair
#homologous recombination
#proximity labeling
#genome editing
#sequencing
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1
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Genome-wide CRISPR screening identifies cellular factors controlling nonviral genome editing efficiency.
(nature.com)
|
Saxena S
…
Saha K
Nature Communications
2026-08-13
|
#crispr
#genome editing
#base-editing
#gene delivery
#screening
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0
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Mechanistic machine learning for prediction of prime editing outcomes.
(nature.com)
|
Hsu A
…
Liu DR
Nature Biotechnology
2026-08-12
|
#genome editing
#machine learning
#base-editing
#prediction
#therapeutics
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0
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UNCOVERseq enables sensitive and controlled gene editing off-target nomination across CRISPR-Cas modalities and systems.
(nature.com)
|
Kinney KJ
…
Kurgan GL
Nature Communications
2026-08-11
|
#crispr
#off-target
#genome editing
#sequencing
#therapeutic
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0
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A self-iterative orthogonal base-editing platform enables multiplex N-to-N diversification and genome-scale functional screening in Escherichia coli.
(academic.oup.com)
|
Fan X
…
Liu R
Nucleic Acids Research
2026-08-10
|
#base-editing
#mutagenesis
#metabolic-engineering
#screening
#genome editing
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0
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Specific cleavage of 5' overhangs of non-target strand by Cas9 activated by target DNA binding.
(academic.oup.com)
|
Lv S
…
Zheng L
Nucleic Acids Research
2026-08-10
|
#crispr
#genome editing
#off-target
#diagnostics
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0
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CRISPR RNA architecture steers Cas9 catalysis and fidelity via a guide repeat clasp motif.
(academic.oup.com)
|
Chilamkurthy R
…
Gagnon KT
Nucleic Acids Research
2026-08-10
|
#crispr
#genome editing
#specificity
#rna structure
#structural biology
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0
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ETfinder: harnessing conserved C-terminal tails of single-stranded DNA-binding proteins for mining and engineering RecET systems in non-model microbial chassis.
(academic.oup.com)
|
Lv D
…
Tan GY
Nucleic Acids Research
2026-08-10
|
#genome editing
#recombineering
#synthetic biology
#metagenomics
#protein design
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0
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Stepwise DNA-unwinding gates TnpB genome-editing activity.
(linkinghub.elsevier.com)
|
Zhou Z
…
Doudna JA
Molecular Cell
2026-08-05
|
#genome editing
#crispr
#endonuclease
#dna unwinding
#protein design
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0
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Rewriting the sarcomere: Gene therapy approaches for hypertrophic cardiomyopathy from bench to bedside.
(linkinghub.elsevier.com)
|
Keen SK
…
Desai MY
Cell Med
2026-07-29
|
#gene therapy
#cardiomyopathy
#sarcomere
#genome editing
#cardiac
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0
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Rapid and Highly Efficient CRISPR-Cas9 RNP Genome Editing in Primary ILC2s.
(onlinelibrary.wiley.com)
|
Candelotti AM
…
Pietropaolo G
European Journal of Immunology
2026-08-01
|
#crispr
#genome editing
#immunity
#lymphocyte
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0
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abCRISPR: deep learning-based design of abasic gRNA sequences for specific CRISPR-Cas genome editing.
(academic.oup.com)
|
Kim GD
…
Wook Chi S
Bioinformatics
2026-07-29
|
#crispr
#deep learning
#genome editing
#off-target
#bioinformatics
|