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5
|
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Proteome-guided drug discovery maps and mitigates therapeutic degrader toxicity.
(nature.com)
|
Basu S
…
Ralser M
Nature Chemical Biology
2026-10-09
|
#proteomics
#degraders
#toxicity
#drug discovery
#cancer
|
|
2
|
|
Large-scale prospective evaluation of co-folding across hundreds of Mac1-ligand complexes and three virtual screens.
(elifesciences.org)
|
Kim J
…
Fraser JS
eLife
2026-10-12
|
#drug discovery
#structure prediction
#deep learning
#affinity
#docking
|
|
2
|
|
ProDTI: Prior-Guided Positive-Unlabeled Learning for Robust Drug-Target Interaction Prediction.
(academic.oup.com)
|
Wang Y
…
Li Y
Bioinformatics
2026-10-07
|
#machine learning
#drug discovery
#deep learning
#protein-protein interaction
#computational biology
|
|
1
|
|
Multiobjective V(H)H discovery through integrated high-throughput screening and AlphaFold3-guided structural prioritization.
(science.org)
|
Overath MD
…
Jenkins TP
Science Advances
2026-10-02
|
#antibody
#screening
#toxins
#structure prediction
#drug discovery
|
|
1
|
|
Predicting and finding geroprotective compounds through modulating conserved longevity-associated aging modules.
(science.org)
|
Huai W
…
Gruber J
Science Advances
2026-10-02
|
#transcriptomics
#aging
#longevity
#drug discovery
#coexpression
|
|
1
|
|
Screening of a chemogenetic library unveils dual-stage antiplasmodials with low cytotoxicity.
(journals.asm.org)
|
Torres L
…
Mitchell G
Antimicrobial Agents and Chemotherapy
2026-10-05
|
#malaria
#drug discovery
#screening
#antiparasitic
#parasitology
|
|
0
|
|
Development of A10P3C, an isoform-selective inhibitor of EGLN2, for targeting breast cancer.
(pnas.org)
|
Liang Q
…
Zhang Q
PNAS
2026-10-01
|
#cancer
#inhibitor
#drug discovery
#transcriptomics
#selectivity
|
|
0
|
|
A small molecule increases mycobacterial translation fidelity without a fitness cost by targeting ribosomal protein S5.
(journals.asm.org)
|
Wu J
…
Javid B
mBio
2026-10-02
|
#tb
#antibiotic-resistance
#translation
#drug discovery
#ribosome
|
|
0
|
|
GCF-anchored and target-oriented mining of metagenomic BGC space for bioactive product discovery.
(journals.asm.org)
|
Yang X
…
Zhang L
Microbiology Spectrum
2026-10-01
|
#metagenomics
#biosynthesis
#drug discovery
#natural products
#cytotoxicity
|