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#breast cancer
— top 20, last 30d
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Giredestrant immobilizes the estrogen receptor to exert potent antitumor efficacy against ER-active breast cancers.
(linkinghub.elsevier.com)
Zhou W
…
Metcalfe C
Cell Chemical Biology
2026-06-18
#breast cancer
#drug development
#estrogen receptor
#protein degradation
#endocrinology
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Rat somatic genome editing enables ER+ breast cancer modeling.
(pnas.org)
Bu W
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Li Y
PNAS
2026-06-22
#genome editing
#cancer
#modeling
#breast cancer
#immunity
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Neoadjuvant stereotactic body radiation therapy with durvalumab and oleclumab in ER(+)HER2(-) breast cancer: a randomized phase 2 trial.
(nature.com)
De Caluwe A
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Buisseret L
Nature Medicine
2026-06-25
#immunotherapy
#breast cancer
#neoadjuvant
#radiation
#checkpoint-inhibitors
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ESR1 mutations and CDK4/6 inhibitor choice shape clonal selection and adaptive cell states during acquired resistance.
(link.springer.com)
Guarducci C
…
Jeselsohn R
Genome Medicine
2026-06-27
#amr
#breast cancer
#clonal evolution
#mutation
#transcriptomics
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H2BE113K mutation promotes breast cancer metastasis through modulating chromatin dynamics.
(science.org)
Hu 胡诗曼 S
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Chan 陈居明 KM
Science Advances
2026-07-10
#epigenetics
#breast cancer
#metastasis
#transcriptomics
#chromatin