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16
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Targeting SUV39H2 exon skipping reverses resistance to CDK4/6 inhibitors via transcriptional activation of p21.
(science.org)
|
Yu S
…
Sun H
Science Advances
2026-10-09
|
#splicing
#breast cancer
#drug resistance
#epigenetics
#senescence
|
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6
|
|
Acute degron-mediated RUNX1 loss reprograms enhancer activity associated with epithelial destabilization and initiation of cancer hallmarks.
(linkinghub.elsevier.com)
|
Fritz AJ
…
Stein GS
Cell Reports
2026-10-07
|
#transcriptomics
#enhancer
#breast cancer
#chromatin
#tumor suppression
|
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4
|
|
ESR1 mutations are associated with enhanced MTORC1 signaling in a context-dependent manner.
(nature.com)
|
De Marchi T
…
Nimeus E
Communications Biology
2026-10-07
|
#proteomics
#breast cancer
#transcriptomics
#signaling
|
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3
|
|
Giredestrant plus Everolimus in Advanced Breast Cancer.
(nejm.org)
|
Mayer EL
…
Rugo HS
New England Journal of Medicine
2026-10-01
|
#breast cancer
#clinical trial
#endocrine therapy
#estrogen receptor
#drug resistance
|
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2
|
|
A noncanonical function of the tyrosine degradation enzyme FAH drives CDK4/6 inhibitor resistance in breast cancer.
(science.org)
|
Hogstrom J
…
Muranen T
Science Advances
2026-10-02
|
#amr
#breast cancer
#cdk-inhibitors
#biomarker
#protein-protein interaction
|
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1
|
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HIF-1-mediated PPME1 expression promotes breast cancer progression via AKT activation and beta-catenin recruitment.
(jci.org)
|
Lyu Y
…
Semenza GL
Journal of Clinical Investigation
2026-10-01
|
#breast cancer
#hypoxia
#immunotherapy
#signaling
#stemness
|
|
1
|
|
Antibody-drug conjugates in breast cancer: redefining targeted therapy.
(jci.org)
|
Guo C
…
Ellisen LW
Journal of Clinical Investigation
2026-10-01
|
#breast cancer
#immunotherapy
#drug delivery
#amr
#biomarker
|
|
1
|
|
Expanding the therapeutic scope of PARP inhibitors in breast cancer: current indications and future directions.
(jci.org)
|
Walmsley CS
…
Lynce F
Journal of Clinical Investigation
2026-10-01
|
#breast cancer
#parp-inhibitors
#homologous recombination
#synthetic lethality
#biomarker
|
|
1
|
|
Breast cancer immunogenicity as a spectrum: evolving concepts and therapeutic implications.
(jci.org)
|
Kay J
…
Loi S
Journal of Clinical Investigation
2026-10-01
|
#immunotherapy
#immunogenicity
#breast cancer
#immunity
#tumors
|
|
1
|
|
A multi-omics analysis of advanced triple-negative breast cancer identifies predictors to chemo-immunotherapy and on-treatment dynamics.
(linkinghub.elsevier.com)
|
Van Renne N
…
Buisseret L
Cell Reports Medicine
2026-09-29
|
#transcriptomics
#immunotherapy
#breast cancer
#biomarker
#microenvironment
|
|
1
|
|
Genome stability disrupted by the circRBM39(4,5,6)-RPA2 axis represses breast tumorigenesis.
(pnas.org)
|
Bian X
…
Wang X
PNAS
2026-09-30
|
#dna repair
#ncrna
#breast cancer
#genome instability
#synthetic lethality
|