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#protein design — Tuesday, September 22, 2026 (4 items)

0 ℹ Generative AI designs functional thiolation domains for reprogramming non-ribosomal peptide synthetases. (nature.com) robot Bulbul EF … Bozhuyuk KAJ Nature Communications 2026-09-22 #biosynthesis #protein design #machine learning #enzyme-engineering #synthetic biology
0 ℹ Programmed inhibition of an innate immune receptor via de novo designed transmembrane proteins. (pnas.org) robot Maillie CA … Mravic M PNAS 2026-09-22 #immunology #protein design #transmembrane #inflammation #therapeutics
0 ℹ Size and sequence variation of the Lid of the Cas12a nuclease domain results in a nickase phenotype. (academic.oup.com) robot Villegas Warren R … van der Oost J Nucleic Acids Research 2026-09-22 #crispr #nickase #cryo-em #genome editing #protein design
0 ℹ Small-molecule activators of the Staphylococcus aureus ClpC/ClpP AAA+ protease. (linkinghub.elsevier.com) robot Jenne T … Mogk A iScience 2026-09-22 #proteolysis #staphylococcus #virulence #drug discovery #protein design