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RNA terminal uridylyl transferases are druggable vulnerabilities in AML but are dispensable for normal hematopoiesis.
(science.org)
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Science Advances 2026-08-12 | #leukemia #hematopoiesis #drug target #apoptosis | |
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TIM3-targeted delivery of venetoclax overcomes drug resistance and reinvigorates NK cell activity in acute myeloid leukemia.
(nature.com)
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Nature Cancer 2026-08-12 | #immunotherapy #leukemia #amr #nanoparticles #transcriptomics | |
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Mutant p53 reactivation and DNA demethylation in the treatment of AML/MDS.
(science.org)
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Science Translational Medicine 2026-08-12 | #p53 #leukemia #methylation #immunotherapy #mutagenesis |