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#hepatocellular carcinoma
— Thursday, August 06, 2026
(3 items)
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PPARalpha activation overcomes fibroinflammatory liver microenvironment-associated anti-PD-1 resistance in hepatocellular carcinoma by mediating GSDME-dependent pyroptosis.
(nature.com)
Chen P
…
Jiang Y
Nature Communications
2026-08-06
#hepatocellular carcinoma
#immunotherapy
#pyroptosis
#microenvironment
#fibrosis
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Non-canonical mTORC1-TFEB activation promotes hepatocyte plasticity and high-grade malignancy in hepatocellular carcinoma.
(jci.org)
Zhang C
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Ding WX
Journal of Clinical Investigation
2026-08-06
#hepatocellular carcinoma
#plasticity
#metabolism
#transcriptomics
#signaling
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Circulating extracellular vesicles carrying PD-1, PD-L1 and CTLA-4 inform resistance to anti-PD-L1-based therapy in HCC.
(gut.bmj.com)
Gorgulho J
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von Felden J
Gut
2026-08-06
#immunotherapy
#hepatocellular carcinoma
#liquid biopsy
#biomarker
#extracellular vesicles