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0
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Functional constraint, not evolutionary domain expansion, is a stronger correlate of pathogenic variant burden in human RNA-binding proteins.
(academic.oup.com)
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Yasuda K
Human Molecular Genetics
2026-07-15
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#pathogenicity
#evolution
#protein-binding
#constraint
#neurodegeneration
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0
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Multiscale brain development across the human lifespan.
(nature.com)
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Ahmad S
…
Yap PT
Communications Biology
2026-07-15
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#neuroimaging
#aging
#connectivity
#neurodegeneration
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0
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Cell-type signatures of Alzheimer's disease shared across population groups.
(nature.com)
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Luquez T
…
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Nature
2026-07-15
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#transcriptomics
#single-cell
#neurodegeneration
#epigenomics
#neuroinflammation
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0
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DDX3X syndrome mutations lock DDX3X-RNA conformational states to drive persistent pathological condensation and neuronal death.
(academic.oup.com)
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Ghosh P
…
Kesavardhana S
Human Molecular Genetics
2026-07-15
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#neurodegeneration
#stress-granules
#neurodevelopmental
#protein misfolding
#structural biology
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0
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Lysosomes and lysosomal dysfunction in ageing biology.
(nature.com)
|
Steinhauser ML
…
Tan JX
Nature Cell Biology
2026-07-15
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#aging
#autophagy
#senescence
#inflammageing
#neurodegeneration
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0
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Functional segregation in Parkinson's disease.
(science.org)
|
Su D
…
Stoessl AJ
Science Advances
2026-07-15
|
#neurodegeneration
#dopamine
#basal ganglia
#neuroimaging
#motor control
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0
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Development of an RNA aptamer as a therapeutic agent for synucleinopathies.
(nature.com)
|
Murakami K
…
Bitan G
Nature Communications
2026-07-15
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#aptamers
#synucleinopathy
#aggregation
#neurodegeneration
#therapeutics
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0
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Microglia integrated neural spheroids enable neuroinflammatory responses and correct network dysfunction induced by alpha-synuclein mutation.
(nature.com)
|
Zhang J
…
Lee EM
Communications Biology
2026-07-15
|
#neuroinflammation
#microglia
#neurodegeneration
#ipsc
#organoid
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0
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Immunotherapy with a short-lived anti-PD-L1 antibody in Alzheimer's disease: a phase 1b, randomized, double-blind trial.
(nature.com)
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Croese T
…
Schwartz M
Nature Medicine
2026-07-15
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#immunotherapy
#neurodegeneration
#neuroinflammation
#antibody
#clinical trial
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0
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The bone-cerebrovascular axis: effects of bone aging on neurovascular dysfunction and neurodegeneration.
(jci.org)
|
Wang J
…
Wan M
Journal of Clinical Investigation
2026-07-15
|
#aging
#neurodegeneration
#endocrine
#cerebrovascular
#osteoporosis
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0
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A small molecule reduces both parkinsonism and l-dopa-induced dyskinesia in animal models of Parkinson's disease.
(science.org)
|
Bordbar A
…
Famili I
Science Translational Medicine
2026-07-15
|
#neurodegeneration
#dyskinesia
#transcriptomics
#therapeutics
#pharmacology
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0
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The effect of physical activity on brain structure and cognitive function in the population-based cohort of LIFE-Adult Study.
(elifesciences.org)
|
Kalc P
…
Gaser C
eLife
2026-07-15
|
#cognition
#neuroimaging
#aging
#epidemiology
#neurodegeneration
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0
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Oligonucleotide-siRNA conjugate for SOD1 amyotrophic lateral sclerosis: a phase 1 trial.
(nature.com)
|
Chen W
…
Wang Y
Nature Medicine
2026-07-15
|
#neurodegeneration
#rnai
#clinical trial
#cns-delivery
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