#protein design — Tuesday, May 05, 2026 (4 items)
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Structural rewiring of IL-7R dimerization by an oncogenic transmembrane mutation can be reversed by rational design.
(pnas.org)
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PNAS 2026-05-05 | #mutation #protein design #leukemia #transmembrane #receptor signaling | |
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Computational design of an ultrapotent deltacoronavirus miniprotein inhibitor.
(pnas.org)
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PNAS 2026-05-05 | #neutralization #protein design #coronavirus #zoonosis #inhibitor | |
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Optimized optogenetic anti-CRISPR for endogenous gene regulation in Drosophila.
(academic.oup.com)
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Nucleic Acids Research 2026-05-05 | #crispr #protein design #gene regulation #neuromodulation | |
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DARPins as pan-reactivators of temperature-sensitive p53 cancer mutants.
(pnas.org)
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PNAS 2026-05-05 | #cancer #protein-stabilization #therapeutics #protein design |