#therapeutics — Monday, January 05, 2026 (1 items)
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Presence of phosphodiester backbone, but not nucleobases, in the guide's 3' terminal region is necessary for RISC loading and target cleavage in vitro and in vivo.
(academic.oup.com)
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Nucleic Acids Research 2026-01-05 | #therapeutics #rnai #chemical modification #gene silencing |