#genome engineering — Monday, January 05, 2026 (2 items)
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Sequential structural rearrangements at the PAM-distal site of a type I-F3 CRISPR-Cas effector enabling RNA-guided DNA transposition.
(academic.oup.com)
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Nucleic Acids Research 2026-01-05 | #dna-binding #cryo-em #crispr #genome engineering #transposition | |
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Directed evolution on compact landing pads yields highly efficient recombinases for large DNA integration.
(academic.oup.com)
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Nucleic Acids Research 2026-01-05 | #genome engineering #gene therapy #directed evolution #recombinase #base-editing |