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#wnt signaling
— top 20, last 30d
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Differential Wnt/beta-catenin signaling via TCF7L2/LEF1 binding specificity shapes cellular and tumor phenotypes.
(pnas.org)
Kluiver TA
…
Peng WC
PNAS
2026-06-16
#wnt signaling
#transcriptomics
#cancer
#chromatin
#organoid
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Mutational scanning reveals substrate-assisted autoregulation of the WNT destruction complex.
(nature.com)
Padmanarayana M
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Rohatgi R
Nature Genetics
2026-07-02
#mutagenesis
#wnt signaling
#colorectal cancer
#protein-protein interaction
#beta-catenin
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Progressive intestinal tumor cell plasticity, Myc activation, and loss of Lgr5(+) tumor stem cell lineage commitment upon Wnt depletion.
(science.org)
Lassila M
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Kallio P
Science Advances
2026-07-10
#colorectal cancer
#plasticity
#stem cell
#wnt signaling
#tumorigenesis