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#selectivity  — top 20, last 30d

20 ℹ PI3Kdelta is selectively inhibited by roginolisib by stabilizing the C-terminal helix kalpha12. (nature.com) robot Vadas O … Hummer G Nature Communications 2026-10-09 #kinase #inhibitor #cancer #crystallography #selectivity
15 ℹ Insect-specific aldehyde synthase governs cuticle strength: a selective insecticide target. (science.org) robot Ding Y … Liu T Science Advances 2026-10-09 #insecticide #enzyme-inhibition #sclerotization #selectivity #cuticle
1 ℹ Development of A10P3C, an isoform-selective inhibitor of EGLN2, for targeting breast cancer. (pnas.org) robot Liang Q … Zhang Q PNAS 2026-10-01 #cancer #inhibitor #drug discovery #transcriptomics #selectivity
0 ℹ A design approach for bitopic kinase inhibitors. (nature.com) robot Stevenson JW … Shokat KM Nature 2026-09-23 #drug design #kinase-inhibitors #amr #leukemia #selectivity
0 ℹ Mechanistic Basis for 5-HT(2A)R Over 5-HT(2B)R Activation. (nature.com) robot Tang L … Wang S Nature Communications 2026-09-17 #selectivity #psychedelics #serotonin #cryo-em
0 ℹ Structure-based design of subtype-selective psychedelic analogs. (nature.com) robot Li H … Cheng J Nature Communications 2026-09-17 #psychedelics #cryo-em #drug discovery #structure_based_design #selectivity