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0
|
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Blocking somatic repeat expansion and lowering huntingtin by RNAi synergize to attenuate Huntington's disease pathogenesis in mice.
(science.org)
|
Belgrad J
…
Khvorova A
Science Translational Medicine
2026-08-12
|
#huntington's
#neurodegeneration
#rnai
#somatic-expansion
#therapeutics
|
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0
|
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Central guide-target pairing activates human Argonaute2 by uncoupling the N-PAZ and MID-PIWI lobes.
(pnas.org)
|
Zhang H
…
Nakanishi K
PNAS
2026-08-10
|
#cryo-em
#rnai
#gene silencing
#structural biology
#catalysis
|
|
0
|
|
Inhibiting Ribosomal RNA Synthesis in C. elegans Protects Against Reductive Stress During de novo Fatty Acid Synthesis Deficiency.
(academic.oup.com)
|
Rotti JF
…
Yerevanian A
Genetics
2026-08-11
|
#redox
#metabolism
#stress response
#rnai
#nematode
|
|
0
|
|
Targeting the E3 ubiquitin ligase RNF10 ameliorates metabolic dysfunction-associated steatohepatitis in mice.
(jci.org)
|
Du C
…
Chang Y
Journal of Clinical Investigation
2026-08-06
|
#steatohepatitis
#lipid metabolism
#ubiquitination
#fibrosis
#rnai
|
|
0
|
|
Divergent C. elegans toxin alleles are suppressed by distinct mechanisms.
(elifesciences.org)
|
Zdraljevic S
…
Kruglyak L
eLife
2026-08-11
|
#toxin-antitoxin
#nematode
#selfish-dna
#transmission
#rnai
|
|
0
|
|
siRNA-guided DNA-methylation at a sucrose transporter gene potentially contributes to climatic plant adaptation.
(journals.plos.org)
|
Li J
…
Liesche J
PLOS Biology
2026-07-30
|
#methylation
#epigenetics
#adaptation
#rnai
#plants
|
|
0
|
|
A small viral protein suppresses immune amplification by two distinct mechanisms.
(journals.asm.org)
|
Liu S
…
Ding S-W
mBio
2026-07-29
|
#virus
#rnai
#immunity
#plants
|