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9
|
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Comparative protein engineering redirects the specificity of Clostridium botulinum proteases.
(linkinghub.elsevier.com)
|
Garrido JE
…
Weiss GA
Cell Chemical Biology
2026-08-26
|
#protein design
#directed evolution
#proteases
#substrate-specificity
#neurotoxins
|
|
8
|
|
Adaptive model-guided protein evolution with sparse data optimizes compact eukaryotic genome editors.
(nature.com)
|
Wan S
…
Gao X
Nature Biotechnology
2026-08-24
|
#protein design
#genome editing
#machine learning
#nucleases
#optimization
|
|
7
|
|
Bright monomeric fluorescent protein elite-niRFP704 for two-channel near-infrared STED nanoscopy.
(pnas.org)
|
Habenstein F
…
Jakobs S
PNAS
2026-08-25
|
#fluorescence
#microscopy
#protein design
#imaging
|
|
6
|
|
Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function.
(linkinghub.elsevier.com)
|
Takacsi-Nagy O
…
Satpathy AT
Cell
2026-08-19
|
#immunotherapy
#protein design
#car-t
#transcriptomics
#epigenetics
|
|
3
|
|
AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins.
(nature.com)
|
Broske B
…
Holzel M
Nature Communications
2026-08-20
|
#protein design
#ai
#immunotherapy
#cancer
#car-t
|
|
3
|
|
Fifteen challenges for generative AI applications to cell biology.
(linkinghub.elsevier.com)
|
Dupire L
…
Califano A
Cell
2026-08-17
|
#ai
#cell biology
#machine learning
#protein design
|
|
2
|
|
Carboxyl-terminal blockade of sortilin binding enhances progranulin gene therapy in a mouse model of frontotemporal dementia.
(science.org)
|
Kashyap SN
…
Roberson ED
Science Translational Medicine
2026-08-19
|
#gene therapy
#neurodegeneration
#frontotemporal-dementia
#neuroinflammation
#protein design
|
|
2
|
|
A blinded, prospective benchmark of in silico antibody discovery anchored to experimental affinity and developability.
(nature.com)
|
Erasmus MF
…
Bradbury ARM
Nature Biotechnology
2026-08-19
|
#antibody
#computational design
#affinity maturation
#machine learning
#protein design
|
|
1
|
|
Engineered HMGB1 construct with tandem Box B domains promotes tissue regeneration without potential for inflammation.
(linkinghub.elsevier.com)
|
Vinals Guitart A
…
Nanchahal J
iScience
2026-08-21
|
#regeneration
#inflammation
#protein design
#immunology
#therapeutics
|
|
1
|
|
Redesign of energetically frustrated regions rescues function in defective T4 clamp loaders.
(academic.oup.com)
|
Nimkar S
…
Kuriyan J
Molecular Biology and Evolution
2026-08-17
|
#protein design
#mutagenesis
#atpase
#phage
#dna replication
|
|
1
|
|
CLDN18.2 antibody design with protein language models: A deep learning optimization framework.
(journals.plos.org)
|
Qu T
…
Cai H
PLOS Computational Biology
2026-08-20
|
#antibody
#deeplearning
#protein design
#immunotherapy
#cancer
|
|
1
|
|
Automated synthetic cell-based screening for designed proteins with emergent functions.
(nature.com)
|
Al Nahas K
…
Schwille P
Nature Communications
2026-08-15
|
#synthetic biology
#protein design
#microfluidics
#screening
#self-organization
|
|
0
|
|
Bridging Linguistic Reasoning and Biophysical Reality Toward Peptide Engineering via Instruction-Tuned Language Modelling.
(academic.oup.com)
|
Yang K
…
Li P
Bioinformatics
2026-08-17
|
#peptide
#language-models
#protein design
#sequence design
#machine learning
|
|
0
|
|
AI-designed prion-capping proteins provide evidence that prion fibril ends are replication-competent surfaces that contribute to prion seeding activity and infectivity.
(journals.asm.org)
|
Slota JA
…
Bailey-Elkin BA
mBio
2026-08-17
|
#prion
#amyloid
#protein design
#replication
#infectivity
|
|
0
|
|
FAF1 and FAF2 enhance unfolding by p97-UFD1-NPL4 complex enabling rational design of p97 activators.
(link.springer.com)
|
Dasgupta P
…
Kulathu Y
The EMBO Journal
2026-08-15
|
#ubiquitination
#proteolysis
#protein design
#structural biology
|