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#e3 ligase  — top 20, last 30d

20 ℹ Multimodal substrate recruitment enables CTLH(MKLN1) E3 ligase to target acetylated N-, C-, and internal degrons. (nature.com) robot Sepic S … Schulman BA Nature Communications 2026-10-17 #ubiquitylation #e3 ligase #cryo-em #proteolysis #substrate-recognition