#drug design — top 20, last 14d
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Small-molecule activation of the tumor suppressor kinase LKB1 via the pseudokinase STRAD.
(linkinghub.elsevier.com)
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Cell Chemical Biology 2026-08-18 | #cancer #kinase #tumor suppression #drug design #allosteric | |
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Orally available Colivin traps TRPV3 in an inactive state and suppresses intestinal inflammation.
(link.springer.com)
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The EMBO Journal 2026-08-13 | #trpv3 #colitis #inflammation #ion channel #drug design | |
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STING agonist profiling by nucleotide library defines structural determinants of cyclic dinucleotide recognition.
(linkinghub.elsevier.com)
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iScience 2026-08-13 | #immunotherapy #sting #innate immunity #drug design #ligand-binding |