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#anticancer
— top 20, last 30d
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Biosynthetic origin of anticancer dolastatin 15 reveals a noncanonical NRPS architecture enabling 2-keto acid activation.
(pnas.org)
Chen M
…
Ding Y
PNAS
2026-09-29
#metagenomics
#biosynthesis
#natural products
#nrps
#anticancer
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Integrative AI-assisted modeling suggests CPPF binding at a composite [Formula: see text]/[Formula: see text]-tubulin interface pocket dominated by [Formula: see text]-tubulin contacts.
(journals.plos.org)
Yang J
…
Li M
PLOS Computational Biology
2026-09-18
#microtubule
#simulation
#anticancer
#protein-modeling
#amr