A Val292 substitution combined with an alanine duplication (ADUP) in the Omega loop of ADC beta-lactamase confers reduced susceptibility to advanced beta-lactam agents, including cefiderocol. (journals.asm.org)

Authors: Kawai A … Doi Y Journal: mBio Published: 2026-05-13 DOI: https://doi.org/10.1128/mbio.03518-25