#structural biology — Monday, August 10, 2026 (3 items)
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Central guide-target pairing activates human Argonaute2 by uncoupling the N-PAZ and MID-PIWI lobes.
(pnas.org)
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PNAS 2026-08-10 | #cryo-em #rnai #gene silencing #structural biology #catalysis | |
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CRISPR RNA architecture steers Cas9 catalysis and fidelity via a guide repeat clasp motif.
(academic.oup.com)
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Nucleic Acids Research 2026-08-10 | #crispr #genome editing #specificity #rna structure #structural biology | |
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In-situ cryo-ET of mouse embryos reveals cytoplasmic lattices contain ubiquitin-charged E2-E3 ligase assemblies.
(link.springer.com)
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The EMBO Journal 2026-08-10 | #cryo-em #ubiquitination #embryogenesis #structural biology #protein complexes |