#genome editing — Monday, April 13, 2026 (3 items)
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DNA-PKcs inhibitor AZD7648 reveals sgRNA cross-contaminants and enhanced sensitivity of genome engineering off-target activity in HSPCs.
(academic.oup.com)
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Nucleic Acids Research 2026-04-13 | #crispr #dna repair #genome editing #off-target #genotoxicity | |
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Precise, specific gene editing via a compact GoCas12m-FokI chimeric nuclease.
(academic.oup.com)
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Nucleic Acids Research 2026-04-13 | #crispr #genome editing #delivery #specificity | |
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Disrupting pegRNA intramolecular complementarity via PBS and spacer sequence alterations can enhance prime editing efficiency.
(academic.oup.com)
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Nucleic Acids Research 2026-04-13 | #genome editing #pegrna #optimization #base-editing |