#off-target — Monday, April 13, 2026 (2 items)
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DNA-PKcs inhibitor AZD7648 reveals sgRNA cross-contaminants and enhanced sensitivity of genome engineering off-target activity in HSPCs.
(academic.oup.com)
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Nucleic Acids Research 2026-04-13 | #crispr #dna repair #genome editing #off-target #genotoxicity | |
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Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.
(academic.oup.com)
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Nucleic Acids Research 2026-04-13 | #therapeutics #rnai #off-target #nucleic acid modification |