#phase separation — Wednesday, April 01, 2026 (3 items)
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STI1 domain engages transient helices to mediate Dsk2 phase separation and proteasome condensation.
(link.springer.com)
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The EMBO Journal 2026-04-01 | #phase separation #chaperone #proteasome #intrinsically disordered regions #protein quality control | |
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ALS mutations disrupt self-association between the ubiquilin STI1 hydrophobic groove and internal placeholder sequences.
(link.springer.com)
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The EMBO Journal 2026-04-01 | #neurodegeneration #phase separation #proteostasis #chaperone | |
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Navigating condensate micropolarity to enhance small-molecule drug targeting.
(nature.com)
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Nature Chemical Biology 2026-04-01 | #modeling #phase separation #condensates #protein design #drug-targeting |