#membrane proteins — Tuesday, February 17, 2026 (3 items)
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Allosteric coupling between PIP(2) and Ca(2+) binding sites gates TMEM16A channels.
(pnas.org)
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PNAS 2026-02-17 | #calcium signaling #ion channel #simulation #membrane proteins #allostery | |
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A two-step clockwork mechanism opens a proteo-lipidic pore in PIEZO2.
(nature.com)
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Nature Chemical Biology 2026-02-17 | #modeling #mechanotransduction #ion channel #membrane proteins | |
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Synaptic transmission: Munc13 assembles onto PI(4,5)P(2)-rich domains into trimers that cooperate to capture vesicles.
(pnas.org)
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PNAS 2026-02-17 | #cryo-em #protein assembly #membrane proteins #synaptic vesicles |