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#ion channel
— Tuesday, February 03, 2026
(2 items)
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The BK channel-NS1619 agonist complex reveals molecular insights into allosteric activation gating.
(pnas.org)
Gonzalez-Sanabria N
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Latorre R
PNAS
2026-02-03
#cryo-em
#ion channel
#simulation
#drug design
#gating
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Chronic and acute modulator treatment restore wild-type-like activity and stability to the primary cystic fibrosis-causing CFTR variant.
(pnas.org)
Rodrat M
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Sheppard DN
PNAS
2026-02-03
#ion channel
#drug therapy
#folding
#cystic fibrosis
#cftr