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#cryo-em — Tuesday, January 06, 2026 (3 items)

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0 ℹ E2 variants for probing E3 ubiquitin ligase activities. (pnas.org) robot Du J … Schulman BA PNAS 2026-01-06 #cryo-em #ubiquitination #protein design #enzyme-specificity
0 ℹ Competition between a transmembrane helix on Scap and a membrane cholesterol regulates Scap-Insig interaction and SREBP activation. (pnas.org) robot Williams BC … Radhakrishnan A PNAS 2026-01-06 #cryo-em #homeostasis #protein structure #cholesterol #membrane proteins
0 ℹ Controlled dynamic remodeling of the spliceosome active site enables the first step of splicing. (pnas.org) robot Martino G … De Vivo M PNAS 2026-01-06 #modeling #splicing #cryo-em #catalysis #spliceosome